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Disclaimer: This guide is for education only and is not a substitute for professional medical advice. Always confirm medicine, supplement and product decisions with your obstetrician, midwife, pharmacist or healthcare provider.

Medication

Is Lisinopril Safe During Pregnancy?

Published 2026-07-12 | By SafeMama Editorial Team | Editorial policy

Is Lisinopril Safe During Pregnancy? pregnancy safety guide image

Short answer

Lisinopril is an ACE inhibitor and is generally avoided after the first trimester because ACE inhibitors can harm fetal kidney development and amniotic fluid levels. Contact your clinician promptly if you take it and are pregnant or trying to conceive.

Avoid after first trimester; call clinician

What is the safest way to think about this?

MotherToBaby says ACE inhibitors should be avoided during the second and third trimesters because they can cause low amniotic fluid and fetal kidney-related problems. The safe action is prompt clinician review, not panic or unsupervised stopping.

What is generally okay?

  • Tell your prescriber as soon as pregnancy is possible or confirmed.
  • Ask what pregnancy-compatible blood-pressure medicine should replace lisinopril and how quickly to switch.
  • Bring dose, dates, and any home blood-pressure readings to the appointment.

What should you avoid or double-check?

  • Avoid continuing lisinopril through pregnancy without specialist direction.
  • Avoid stopping all blood-pressure treatment without a replacement plan.
  • Avoid ACE inhibitors or ARBs in later pregnancy unless a specialist documents an exceptional reason.

How SafeMama helps

SafeMama can flag lisinopril, Zestril, ACE inhibitors, and related blood-pressure medicines so users can ask about pregnancy alternatives quickly.

Open the SafeMama app, scan the barcode or search the ingredient, then use the result as a starting point for a conversation with your healthcare provider.

Sources

Frequently asked questions

What if I took lisinopril before I knew I was pregnant?

Contact your clinician with the dose and dates. They can switch therapy and decide whether any extra monitoring is needed.

Can untreated high blood pressure be risky too?

Yes. That is why you should not simply stop treatment without a replacement plan from your clinician.

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